Crotonyl fentanyl Chemical Properties

solubility 

DMF: 30 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml

form 

A neat solid

Safety Information

DEA Controlled Substances

CSCN: 9844
CSA SCH: Schedule I
NARC: Yes

Crotonyl fentanyl Usage And Synthesis

Description

Crotonyl fentanyl is an analytical reference material categorized as an opioid.^1,2,3 Crotonyl fentanyl induces generalized responses in mice trained to discriminate oxycodone from saline.⁴ Crotonyl fentanyl is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications.

Uses

Crotonyl Fentanyl is an analog of Fentanyl (F274990), which is a controlled substanced used as analgesic.

References

1. Eshleman, A.J., Nagarajan, S., Wolfrum, K.M., et al. Affinity, potency, efficacy, selectivity, and molecular modeling of substituted fentanyls at opioid receptors Biochem. Pharmacol. 182,114293(2020).
2. Vasudevan, L., Vandeputte, M.M., Deventer, M., et al. Assessment of structure-activity relationships and biased agonism at the mu opioid receptor of novel synthetic opioids using a novel, stable bio-assay platform Biochem. Pharmacol. 177,113910(2020).
3. Varshneya, N.B., Walentiny, D.M., Moisa, L.T., et al. Opioid-like antinociceptive and locomotor effects of emerging fentanyl-related substances Neuropharmacology 151,171-179(2019).
4. Walentiny, D.M., Moisa, L.T., and Beardsley, P.M. Oxycodone-like discriminative stimulus effects of fentanyl-related emerging drugs of abuse in mice Neuropharmacology 150,210-216(2019).