Methylcardol triene Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMF: 20 mg/ml; DMSO: 15 mg/ml; Ethanol: 22 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml

form 

A neat oil

Methylcardol triene Usage And Synthesis

Description

Methylcardol triene is a phenol found in cashew nut shell liquid that inhibits α-glucosidase (IC₅₀ = 39.6 μM).¹ It is schistosomicidal, killing 100% of adult S. mansoni worms after 24 hours when used at concentrations of 100 and 200 μM.² It has been used as a starting material for the synthesis of mono- and bis-benzoxazines.³

References

1. Toyomizu, M., Sugiyama, S., Jin, R.L., et al. α-Glucosidase and aldoser reductase inhibitors: Constituents of cashew, anacardium occidentale, nut shell liquids Phytother. Res. 7,252-254(1993).
2. Attanasi, O.A., Behalo, M.S., Favi, G., et al. Solvent free synthesis of novel mono- and bis-benzoxazines from cashew nut shell liquid components Curr. Org. Chem. 16(21),2613-2621(2012).