BRL 15572 hydrochloride
BRL 15572 hydrochloride Basic information
- Product Name:
- BRL 15572 hydrochloride
- Synonyms:
-
- CS-1063
- BRL-15572; BRL15572 ; BRL 15572 DIHYDROCHLORIDE; BRL15572 DIHYDROCHLORIDE
- CAS:
- 1173022-77-9
- MF:
- C25H28Cl2N2O
- MW:
- 443.41
- Mol File:
- 1173022-77-9.mol
BRL 15572 hydrochloride Chemical Properties
- solubility
- Soluble in DMSO (10mM) or ethanol (50mM)
BRL 15572 hydrochloride Usage And Synthesis
Uses
BRL 15572 Hydrochloride is an analog of BRL 15572, which is a preferential antagonist at native human 5-HT1D receptors.
Definition
ChEBI: 3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol hydrochloride is a hydrochloride that is the monohydrochloride salt of 3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol. A selective h5-HT1D antagonist, displaying 60-fold selectivity over h5-HT1B, and exhibiting little or no affinity for a range of other receptor types. It has a role as a serotonergic antagonist and a prodrug. It contains a 4-(3-chlorophenyl)-1-(2-hydroxy-3,3-diphenylpropyl)piperazin-1-ium(1+).
in vivo
BRL-15572 prevents (-)-epicatechin-induced antinociception in the formalin test[2].
BRL-15572 (0.3-100.0 mg/kg; i.p.) is inactive and BRL-15572 (0.1-10 mg/kg; i.p.) has no effect on body temperature the guinea pig[3].
IC 50
5-HT1D Receptor
storage
+4°C (desiccate)
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