Compound 7 Chemical Properties

Density 

1.28±0.1 g/cm3(Predicted)

pka

8.95±0.10(Predicted)

form 

Solid

color 

Off-white to light yellow

Compound 7 Usage And Synthesis

Description

HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor that has antitumor activity.

Uses

HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor with pIC50s of 7.2 and 6.8 in BRET assay, respectively. Antitumoral activity[1].

References

[1] Géraldy M, et al. Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated. J Med Chem. 2019 May 9;62(9):4426-4443. DOI:10.1021/acs.jmedchem.8b01936