GK187 Chemical Properties

Boiling point:

330.3±42.0 °C(Predicted)

Density 

1.225±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF:10.0(Max Conc. mg/mL);32.23(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);96.69(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);32.23(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.97(Max Conc. mM)

form 

Liquid

color 

Colorless to light yellow

GK187 Usage And Synthesis

Description

GK187 is an inhibitor of Group VIA (GVIA) calcium-independent phospholipase A₂ (iPLA₂), an enzyme involved in basal cell metabolism. It inhibits GVIA iPLA₂ by 99.8% at 0.091 mole fraction in a mixed micelle activity assay and is selective for GVIA iPLA₂ over GIVA cPLA₂ and GV sPLA₂ where it shows less than 25% and 32.8% inhibition, respectively.

Uses

GK187 is a very potent and selective GVIA iPLA2 inhibitor.