GSK690 Chemical Properties

Boiling point:

530.5±50.0 °C(Predicted)

Density 

1.21±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: 2mg/mL, clear

pka

9.91±0.10(Predicted)

form 

powder

color 

white to beige

InChI

1S/C24H23N3O/c1-17-2-6-21(7-3-17)24-23(20-8-4-18(13-25)5-9-20)12-22(15-27-24)28-16-19-10-11-26-14-19/h2-9,12,15,19,26H,10-11,14,16H2,1H3/t19-/m1/s1

InChIKey

IQVDLEXWAPYWDT-LJQANCHMSA-N

SMILES

N#CC1=CC=C(C2=CC(OC[C@H]3CNCC3)=CN=C2C4=CC=C(C)C=C4)C=C1

Safety Information

WGK Germany 

WGK 3

Storage Class

11 - Combustible Solids

GSK690 Usage And Synthesis

Description

GSK-690 is a potent and selective Reversible Inhibitors of Lysine Specific Demethylase 1.

Uses

GSK 690 is a reversible inhibitor of lysine specific demethylase 1 (LSD1), with a Kd value of 9 nM and a biochemical IC50 of 37 nM.

References

[1] Mould DP, et al. Development of (4-Cyanophenyl)glycine Derivatives as Reversible Inhibitors of Lysine Specific Demethylase 1. J Med Chem. 2017 Oct 12;60(19):7984-7999. DOI:10.1021/acs.jmedchem.7b00462
[2] Haydn T, et al. Concomitant epigenetic targeting of LSD1 and HDAC synergistically induces mitochondrial apoptosis in rhabdomyosarcoma cells. Cell Death Dis. 2017 Jun 15;8(6):e2879. DOI:10.1038/cddis.2017.239