Y06036
Y06036 Basic information
- Product Name:
- Y06036
- Synonyms:
-
- Y06036
- Benzenesulfonamide, 5-bromo-2-methoxy-N-(6-methoxy-3-methyl-1,2-benzisoxazol-5-yl)-
- inhibit,Epigenetic Reader Domain,Inhibitor,Y-06036,Y 06036,Y06036
- 5-Bromo-2-methoxy-N-(6-methoxy-3-methylbenzo[d]isoxazol-5-yl)benzenesulfonamide
- Y06036, 10 mM in DMSO
- CAS:
- 1832671-96-1
- MF:
- C16H15BrN2O5S
- MW:
- 427.27
- Mol File:
- 1832671-96-1.mol
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Y06036 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO : 130 mg/mL (304.26 mM)
- form
- Solid
- color
- Light yellow to yellow
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Y06036 Usage And Synthesis
Uses
Y06036 is CRPC inhibitor.
in vivo
Y06036 (50 mg/kg, i.p. injection, 5 times per week, 25 days) demonstrates therapeutic effects in a C4-2B CRPC xenograft tumor model in mice. Y06036 is well tolerated in the treated mice, based on the weight of the animal body and their general behavior[1].
| Animal Model: | Four-week-old male mice (strain: C.B-17/IcrHsd-Prkdcscid for C4-2B) with C4-2B mouse xenograft model[1] |
| Dosage: | 50 mg/kg, 100 μL |
| Administration: | Intraperitoneal (i.p.) injection, 5 times per week, 25 days |
| Result: | Exhibited strong antitumor activities during the 25-day treatment period, with a tumor growth inhibition (TGI) of 70%. |
IC 50
BRD4(1): 82 nM (Kd)
Y06036Supplier
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com
ShangHai Biochempartner Co.,Ltd
- Tel
- 177-54423994 17754423994
- 2853530910@QQ.com
Beijing Jin Ming Biotechnology Co., Ltd.
- Tel
- 010-60605840 18892239720
- psaitong@jm-bio.com
Shanghai Yu Ben Biotechnology Co., Ltd.
- Tel
- 021-61350663 15502154572
- 1639466865@qq.com
Fan De(Beijing) Biotechnology Co., Ltd.
- Tel
- 15911056312
- liming@bio-fount.com