7-oxaspiro[3.5]nonan-2-amine Chemical Properties

Boiling point:

228.5±40.0 °C(Predicted)

Density 

1.04±0.1 g/cm3(Predicted)

pka

10.52±0.20(Predicted)

7-oxaspiro[3.5]nonan-2-amine Usage And Synthesis

Synthesis

The synthetic route for 7-oxaspiro[3.5]nonan-2-amine typically uses the corresponding ketone compound 7-oxaspiro[3.5]nonane-2-one as a key intermediate. First, a ketone with an oxaspiro[3.5]nonane skeleton is constructed via a multi-step organic synthesis, where the four-membered oxaspirobutane ring and the six-membered tetrahydropyran ring are linked by a common carbon atom. After obtaining the ketone intermediate, the final amine compound is obtained through reductive amination: 7-oxaspiro[3.5]nonane-2-one reacts with an ammonia source (e.g., ammonium acetate or liquid ammonia) in a suitable solvent to generate an imine intermediate. This imine intermediate is then reduced with a reducing agent (e.g., sodium borohydride or sodium triacetoxyborohydride) to convert the ketone group (C=O) to a primary amine group (C-NH2), thus yielding the target product 7-oxaspiro[3.5]nonan-2-amine.