Squarunkin A
Squarunkin A Basic information
- Product Name:
- Squarunkin A
- Synonyms:
-
- Squarunkin A
- 1-Piperidinecarboxylic acid, 4-[[3,4-dioxo-2-[[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]amino]-1-cyclobuten-1-yl]amino]-, ethyl ester
- ethyl 4-({3,4-dioxo-2-[(2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}ethyl)amino]cyclobut-1-en-1-yl}amino)piperidine-1-carboxylate
- CAS:
- 2101958-02-3
- MF:
- C25H32F3N5O4
- MW:
- 523.55
- Mol File:
- 2101958-02-3.mol
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Squarunkin A Chemical Properties
- Boiling point:
- 629.1±65.0 °C(Predicted)
- Density
- 1.36±0.1 g/cm3(Predicted)
- pka
- 7.22±0.10(Predicted)
- form
- Solid
- color
- White to off-white
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Squarunkin A Usage And Synthesis
Uses
Squarunkin A is a potent and selective UNC119-cargo interaction inhibitor, interrupting the UNC119A-myristoylated Src N-terminal peptide interaction (IC50=10 nM). Squarunkin A interferes with the activation of Src kinase in cells[1].
References
[1] Tom Mejuch, et al. Small-Molecule Inhibition of the UNC119-Cargo Interaction. Angew Chem Int Ed Engl. 2017 May 22;56(22):6181-6186. DOI:10.1002/anie.201701905
Squarunkin ASupplier
Shanghai Lollane Biological Technology Co.,Ltd.
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