Cyclizine Hydrochloride Chemical Properties

Melting point:

258-260℃

Boiling point:

457.04°C (rough estimate)

Density 

1.0551 (rough estimate)

refractive index 

1.5749 (estimate)

storage temp. 

Refrigerator

solubility 

Methanol: 1 mg/ml

Safety Information

Hazard Codes 

T

Risk Statements 

61-23/24/25-42/43

Safety Statements 

53-22-36/37/39-45

RIDADR 

3249

WGK Germany 

3

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

2933595960

Toxicity

mouse,LD50,intraperitoneal,58mg/kg (58mg/kg),Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 13, Pg. 241, 1975.

Cyclizine Hydrochloride Usage And Synthesis

Chemical Properties

Off-White Solid
moderately soluble in water

Originator

Marezine,BurroughsWellcome,US,1953

Uses

Cyclizine Hydrochloride is a piperazine derivative with anti-emetic activity that is useful in the prevention and treatment of nausea and vomiting associated with motion sickness. Antiemetic.

Uses

Motion sickness (prophylaxis and treatment)—Oral cyclizine is indicated for the prophylaxis and treatment of nausea, vomiting, and dizziness associated with motion sickness. Nausea and vomiting, postoperative (prophylaxis and treatment)—to prevent or reli

Definition

ChEBI: Cyclizine hydrochloride is a hydrochloride salt consisting of equimolar amounts of cyclizine and hydrogen chloride. It has a role as a H1-receptor antagonist, a central nervous system depressant, a cholinergic antagonist and an antiemetic. It contains a cyclizine.

Manufacturing Process

One-tenth mol (20 g) of benzhydryl chloride was mixed with 0.19 mol (19 g) of N-methylpiperazine and about 10 cc of benzene and the whole was heated on the steam bath four hours. The contents of the flask was partitioned between ether and water, and the ethereal layer was washed with water until the washings were neutral. The base was then extracted from the ethereal layer by N hydrochloric acid and the extract, made acid to Congo red paper, was evaporated under vacuum. 29.5 g of the pure dihydrochloride of Nmethyl-N'-benzhydryl piperazine was recovered from the residue by recrystallization from 95% alcohol melting above 250°C with decomposition. The addition of alkali to an aqueous solution of the dihydrochloride liberated the base which was recovered by recrystallization from petroleum ether melting at 105.5° to 107.5°C.

Therapeutic Function

Antinauseant

Cyclizine Hydrochloride(303-25-3)Related Product Information

• Cyclizine