Ac4GalNAl Chemical Properties

Boiling point:

570.1±50.0 °C(Predicted)

Density 

1.28±0.1 g/cm3(Predicted)

pka

12.63±0.70(Predicted)

Ac4GalNAl Usage And Synthesis

Uses

Ac4GalNAlk is a weakly alkyne-labeled reagent for metabolic oligosaccharide engineering (MOE) that can be used to detect protein glycosylation. MOE reagents can be activated by cellular biosynthetic machinery into nucleotide sugars, which can be further traced through the introduction of glycoproteins in bioorthogonal chemistry. Ac4GalNAlk promotes nucleotide-sugar biosynthesis and increases bioorthogonal cell surface markers[1].

References

[1] Cioce A, et al. Optimization of Metabolic Oligosaccharide Engineering with Ac4GalNAlk and Ac4GlcNAlk by an Engineered Pyrophosphorylase. ACS Chem Biol. 2021 Oct 15;16(10):1961-1967. DOI:10.1021/acschembio.1c00034

Ac4GalNAl(1810852-60-8)Related Product Information

• Ac4ManNAz
• N–(4–pentynoyl) mannosamine tetraacylated (Ac4ManNAl)
• 2-[(Azidoacetyl)amino]-2-deoxy-D-glucopyranose 1,3,4,6-tetraacetate
• N-azidoacetylgalactosamine-tetraacylated (Ac4GaINAz)
• Ac4GlcNAl