2-(4-CHLOROPHENYL)-4-(4-FLUOROPHENYL)-5-PYRIDIN-4-YL-1,2-DIHYDROPYRAZOL-3-ONE Chemical Properties

Boiling point:

534.1±60.0 °C(Predicted)

Density 

1.388±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

DMF: 5 mg/ml; DMSO: 5 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: 0.3 mg/ml

form 

A crystalline solid

pka

6.61±0.10(Predicted)

color 

Light yellow to yellow

2-(4-CHLOROPHENYL)-4-(4-FLUOROPHENYL)-5-PYRIDIN-4-YL-1,2-DIHYDROPYRAZOL-3-ONE Usage And Synthesis

Uses

p38 MAPK-IN-4 (compound 6) is a p38 MAPK inhibitor with an 50 of 35 nM[1].

Biological Activity

Cell permeable: no', 'Product does not compete with ATP.', 'Reversible: no

IC 50

p38: 35 nM (IC₅₀)

References

[1] S E de Laszlo, et al. Pyrroles and other heterocycles as inhibitors of p38 kinase. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2689-94. DOI:10.1016/s0960-894x(98)00495-8

2-(4-CHLOROPHENYL)-4-(4-FLUOROPHENYL)-5-PYRIDIN-4-YL-1,2-DIHYDROPYRAZOL-3-ONE(219138-24-6)Related Product Information

• P38 Mapk Inhibitor