BMY 45778 Chemical Properties

Boiling point:

659.9±65.0 °C(Predicted)

Density 

1.298±0.06 g/cm3(Predicted)

storage temp. 

room temp

solubility 

≥67.6 mg/mL in DMSO

form 

powder

pka

3.10±0.10(Predicted)

color 

white to beige

BMY 45778 Usage And Synthesis

Uses

BMY 45778 is an agonist for IP receptor to up-regulate the expression of C?/EBPβ and C?/EBPδ.

Definition

ChEBI: BMY 45778 is a bisoxazole. It has a role as a partial prostacyclin agonist.

Biological Activity

Non-prostanoid prostacyclin mimetic that acts as a partial agonist at IP 1 prostacyclin receptors. Potently inhibits platelet aggregation in vitro (IC 50 = 27-35 nM).

Biochem/physiol Actions

BMY 45778 is a non-prostanoid prostacyclin agonist.

References

[1]. seiler sm, brassard cl, federici me, et al. [3-[4-(4,5-diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid (bmy 45778) is a potent non-prostanoid prostacyclin partial agonist: effects on platelet aggregation, adenylyl cyclase, camp levels, protein kinase, and iloprost binding. prostaglandins, 1997, 53(1): 21-35.
[2]. wise h, qian ym, jones rl. a study of prostacyclin mimetics distinguishes neuronal from neutrophil ip receptors. eur j pharmacol, 1995, 278(3): 265-269.

BMY 45778(152575-66-1)Related Product Information

• 2-METHYL-4,5-DIPHENYLOXAZOLE
• 5-(4-METHOXYPHENYL)OXAZOLE
• BMY 45778