3-ACETYLPYRIDINE ADENINE DINUCLEOTIDE Chemical Properties

storage temp. 

−20°C

solubility 

PBS (pH 7.2): 10 mg/ml

form 

A crystalline solid

color 

White to light yellow

biological source

Porcine brain

Water Solubility 

water: 50mg/mL, clear, colorless to faintly yellow

InChIKey

KPVQNXLUPNWQHM-MFRNWTRNNA-N

SMILES

O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP([O-])(=O)OC[C@@H]2[C@H]([C@@H](O)[C@H]([N+]3=CC=CC(C(=O)C)=C3)O2)O)O[C@H]1N1C=NC2C(=NC=NC1=2)N)O |&1:1,2,3,15,16,17,19,32,r|

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

2934999090

MSDS

• Language:English Provider:SigmaAldrich

3-ACETYLPYRIDINE ADENINE DINUCLEOTIDE Usage And Synthesis

Description

3-Acetylpyridine NAD (APAD) is an analog of NAD⁺ (free acid) (nicotinamide adenine dinucleotide; ), a signaling molecule and cofactor or substrate for many enzymes. APAD has been used to study the mechanisms of oxidative phosphorylation. It can be reduced by transdehydrogenase from NADH (sodium salt) . It can be reduced more efficiently and is more stable than NAD⁺; thus, it is useful as a substitute.

Uses

3-Acetylpyridine adenine dinucleotide, 90% is an analog of nicotinamide adenine dinucleotide (NAD). 33-Acetylpyridine adenine dinucleotide, 90% collaboratively inhibits Lactate Dehydrogenase (LDH) with bisulfite[1][2].

Definition

ChEBI: 3-acetylpyridine adenine dinucleotide is an organic molecular entity.

References

[1] Boland MJ. NADH-dependent glutamate synthase from lupin nodules. Reactions with oxidised and reduced 3-acetylpyridine-adenine dinucleotide. Eur J Biochem. 1981 Apr;115(3):485-9. PMID:7238515
[2] Ciaccio EI. The inhibition of lactate dehydrogenase by 3-acetylpyridine adenine dinucleotide and bisulfite. J Biol Chem. 1966 Apr 10;241(7):1581-6. PMID:5946616

3-ACETYLPYRIDINE ADENINE DINUCLEOTIDE(86-08-8)Related Product Information

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• 3-ACETYLPYRIDINE ADENINE DINUCLEOTIDE