Basic information Safety Supplier Related

FENPIVERINIUM BROMIDE

Basic information Safety Supplier Related

FENPIVERINIUM BROMIDE Basic information

Product Name:
FENPIVERINIUM BROMIDE
Synonyms:
  • 1-(3-carbamoyl-3,3-diphenylpropyl)-1-methyl-piperidiniubromide
  • 1-(4-amino-4-oxo-3,3-diphenylbutyl)-1-methyl-piperidiniubromide
  • 12494hoechst
  • diphenyl-piperidino-aethyl-acetamid-brommethylat
  • fenpiverinium
  • resantin
  • FENPIVERINIUM BROMIDE
  • 1-(3-CarbaMoyl-3,3-diphenylpropyl)-1-MethylpiperidiniuM BroMide
CAS:
125-60-0
MF:
C22H29BrN2O
MW:
417.38
EINECS:
204-744-9
Product Categories:
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
125-60-0.mol
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FENPIVERINIUM BROMIDE Chemical Properties

Melting point:
177.5-178.5?C
storage temp. 
Refrigerator
solubility 
Methanol (Slightly), Water (Slightly, Heated)
form 
Solid
color 
White to Off-White
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FENPIVERINIUM BROMIDE Usage And Synthesis

Chemical Properties

Crystalline Solid

Originator

Fenpiverinium bromide,R L Fine Chem

Uses

Anticholinergic. Antispasmodic.

Manufacturing Process

17.5 g diphenylpiperidine ethyl acetonitrile, prepared from sodium amide and 2-piperidinoethyl chloride (D.B. Patent No. 710,227) was heated to reflux with 35 g KOH, 70 ml ethanol and 2 ml water for 6 hours. On cooling rich white crystals dropped. They was filtered off, washed with water to neutral and dried. Then the product was recrystallized from ethanol. Yield of diphenylpiperidine ethyl acetamide 15 g. MP: 186°-187°C.
10 g diphenylpiperidine ethyl acetamide was mixed with 42 g of 17% solution methyl bromide in benzene and 60 ml isopropanol and heated to reflux on a steam bath for 0.5 hour. The solvent was distilled in vacuum to dryness, dissolved in 100 ml of water and the very muddy solution was through a coal filtered. The clear filtrate was distilled off to dryness. Fenpiverinium bromide was light dissolved in water and had neutral reaction.

Therapeutic Function

Spasmolytic

FENPIVERINIUM BROMIDESupplier

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