2-(2-Methylphenoxy)-4H-1,3,2-benzodioxaphosphorin 2-oxide
2-(2-Methylphenoxy)-4H-1,3,2-benzodioxaphosphorin 2-oxide Basic information
- Product Name:
- 2-(2-Methylphenoxy)-4H-1,3,2-benzodioxaphosphorin 2-oxide
- Synonyms:
-
- 2-(2-cresyl)-4h-1-3-2-benzodioxaphosphorin-2-oxide
- 2-(o-cresyl)-4h-1,3,2-benzodioxaphoran-2-one
- 3,2-benzodioxaphosphorin,2-(2-methylphenoxy)-4h-2-oxide
- 3,2-benzodioxaphosphorin,2-(o-tolyloxy)-4h-2-oxide
- cbdp
- phosphoricacid,cyclicmethylene-o-phenyleneo-tolylester
- o-Tolyl saligenin phosphate
- 2-(2-METHYLPHENOXY)-4H-1,3,2-BENZODIOXAPHOSPHORIN 2-OXIDE
- CAS:
- 1222-87-3
- MF:
- C14H13O4P
- MW:
- 276.22
- Mol File:
- 1222-87-3.mol
2-(2-Methylphenoxy)-4H-1,3,2-benzodioxaphosphorin 2-oxide Chemical Properties
- Boiling point:
- 362.4±42.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
2-(2-Methylphenoxy)-4H-1,3,2-benzodioxaphosphorin 2-oxide Usage And Synthesis
Uses
Plasma carboxylic-ester hydrolase (EC3.1.1.1) is a very important detoxification route for the toxic stereoisomers of soman. Detoxification is meant in the sense that if soman was bound to carbox-ylic-ester hydrolase, it was not free to inhibit acetylcholinesterase. CBDP (2-(2-Methylphenoxy)-4H-1,3,2-benzodioxaphosphorin 2-oxide) pretreatment, which inhibited irreversibly carboxylic-ester hydrolase activity without inhibiting phosphoryl phosphatase activity, potentiated the toxicity of soman in mice. In toxicity experiments, CBDP (0.5 mg/kg; iv 1 hr prior to soman) pretreatment potentiated the toxicity of C(±)P(±)-, C(+)P(?)-, and C(?)P(?)-soman to a similar degree[1].
References
[1] John G. Clement. “Stereoisomers of soman (pinacolyl methylphosphonofluoridate): Inhibition of serum carboxylic ester hydrolase and potentiation of their toxicity by CBDP (2-(2-methylphenoxy)-4H-1,3,2-benzodioxaphosphorin-2-oxide) in mice.” Toxicology and applied pharmacology 89 1 (1987): Pages 141-143.
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