L-759,633 Chemical Properties

Boiling point:

447.9±45.0 °C(Predicted)

Density 

0.956±0.06 g/cm3(Predicted)

storage temp. 

Store at +4°C

solubility 

Ethanol:20.0(Max Conc. mg/mL);52.0(Max Conc. mM)
PBS (pH 7.2):0.25(Max Conc. mg/mL);0.65(Max Conc. mM)

L-759,633 Usage And Synthesis

Description

L-759,633 is a high-affinity peripheral cannabinoid receptor (CB₂)-selective agonist with K_i values of 6.4 and 1,043 nM for CB₂ and central cannabinoid (CB₁) receptors, respectively. L-759,633 inhibits forskolin-stimulated cyclic AMP production in CHO cells transfected with CB₂ or CB₁ receptors with IC₅₀ values of 8.1 nM and 10 μM, respectively.

Uses

L 759633 is a cannabinoid receptor (CB2) selective agonist and a structural analogues of ??9-Tetrahydro Cannabinol, an active constituent of cannabis. L 759633 has analgesic and anti-inflammatory properties.

Definition

ChEBI: 6h-dibenzo[b,d]pyran, 3-(1,1-dimethylheptyl)-6a,7,10,10a-tetrahydro-1-methoxy-6,6,9-trimethyl-, (6ar,10ar)- is a 1-benzopyran.

Biological Activity

High affinity, selective CB 2 receptor agonist (K i values are 6.4 and 1043 nM for CB 2 and CB 1 receptors respectively). Potently inhibits forskolin-stimulated cAMP production via CB 2 receptors expressed in CHO cells (EC 50 = 8.1 nM).

L-759,633(174627-50-0)Related Product Information

• DELTA-8-THC
• L-759,633
• 5-(1,1-DIMETHYL-HEPTYL)RESORCINOL
• 4-(2-ETHOXYPHENYL)-2-METHYL-1-BUTENE
• 1-(1 1-DIMETHYLHEPTYL)-3 5-DIMETHOXYBEN&
• ethyl-delta-8-tetrahydrocannabinol
• (6AR,10AR)-3-(1,1-DIMETHYLBUTYL)-6A,7,10,10A-TETRAHYDRO-6,6,9-TRIMETHYL-6H-DIBENZO[B,D]PYRAN