CJC -1295 whitout DAC
CJC -1295 whitout DAC Basic information
- Product Name:
- CJC -1295 whitout DAC
- Synonyms:
-
- L-Argininamide, L-tyrosyl-D-alanyl-L-α-aspartyl-L-alanyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-glutaminyl-L-seryl-L-tyrosyl-L-arginyl-L-lysyl-L-valyl-L-leucyl-L-alanyl-L-glutaminyl-L-leucyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-leucyl-L-glutaminyl-L-α-aspartyl-L-isoleucyl-L-leucyl-L-seryl-
- L-tyrosyl-D-alanyl-L-α-aspartyl-L-alanyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-glutaminyl-L-seryl-L-tyrosyl-L-arginyl-L-lysyl-L-valyl-L-leucyl-L-alanyl-L-glutaminyl-L-leucyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-leucyl-L-glutaminyl-L-α-aspartyl-L-isoleucyl-L-leucyl-L-seryl-L-argininamide
- CJC -1295 whitout DAC
- CIC-1295 With DAC
- CAS:
- 446036-97-1
- MF:
- C152H252N44O42
- MW:
- 3367.9
- Mol File:
- 446036-97-1.mol
CJC -1295 whitout DAC Chemical Properties
- Density
- 1.43±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: slightly soluble,DMSO: 1mg/mL,Ethanol: slightly soluble
- form
- A crystalline solid
CJC -1295 whitout DAC Usage And Synthesis
Biological Activity
CJC-1295 is a synthetic peptide derivative of growth hormone-releasing hormone (GHRH).1 Unlike CJC-1295-DAC, CJC-1295 does not contain a drug affinity complex (DAC) moiety and has a shorter half-life than the DAC-conjugated version in the blood.2 CJC-1295 increases the secretion of growth hormone in primary rat anterior pituitary cells when used from picomolar to micromolar concentrations and into rat blood when administered subcutaneously at a dose of 1 μmol/kg.1
References
1.Bridon, D.P., Boudjellab, N., Leger, R., et al.Long lasting growth hormone releasing factor derivatives(2002) 2.Teichman, S.L., Neale, A., Lawrence, B., et al.Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adultsJ. Clin. Endocrinol. Metab.91(3)799-805(2006)
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