Basic information Safety Supplier Related

Fondaparinux

Basic information Safety Supplier Related

Fondaparinux Basic information

Product Name:
Fondaparinux
Synonyms:
  • Fondaparinux
  • alpha-D-Glucopyranoside, methyl o-2-deoxy-6-o-sulfo-2-(sulfoamino)-alpha-D-glucopyranosyl-(1-4)-o-beta-D-glucopyranuronosyl-(1-4)-o-2-deoxy-3,6-di-o-sulfo-2-(sulfoamino)-alpha-D-glucopyranosyl-(1-4)-o-2-o-sulfo-alpha-L-idopyranuronosyl-(1-4)-2-deoxy-2-(sulfoamino)-, 6-(hydrogen sulfate)
  • Natural heparin pentasaccharide
  • Sr 90107
  • Unii-J177fow5jl
CAS:
816468-88-9
MF:
C31H53N3O49S8
MW:
1508.26322
Mol File:
816468-88-9.mol
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Fondaparinux Usage And Synthesis

Mechanism of action

The development of fondaparinux, a synthetically derived pentasaccharide that binds specifically to and activates antithrombin III, is a further refinement on the mechanism of action of heparin. Fondaparinus and a related analogue, idraparinux, are specific, indirect inhibitors of activated factor Xa via their activation of antithrombin. Fondaparinux has strategically located sulfonates that bind to antithrombin. Fondaparinux is structurally related to the antithrombotic binding site of heparin. Unlike heparin or LMWHs, however, these inhibitors have no effect on thrombin, because they lack the longer saccharide chains required for binding to thrombin. The highly sulfated heparins exhibit nonselective binding to a number of additional proteins, resulting in decreased bioavailability and significant variation in activity.

Pharmacokinetics

Fondaparinux is administered via subcutaneous injection with a single daily dose and shows complete absorption. The drug is highly bound to antithrombin III (~94%), with no significant binding to other plasma proteins. Because of the predictable anticoagulant effect, the drug does not require routine coagulation monitoring. The drug is not metabolized and is excreted in the urine unchanged within 72 hours in patients with normal renal function. Fondaparinux has an elimination half-life of 17 hours. Presently, no clinically significant drug interactions have been reported.

Clinical Use

Fondaparinux is the first selective factor Xa inhibitor that is approved for the prophylaxis of DVT, which may occur in patients undergoing hip fracture surgery or hip or knee replacement surgery (59).

Side effects

The most common side effect is major and minor bleeding, and the patient must be carefully monitored. The drug is not to be used when spinal anesthesia or spinal puncture is employed because of the potential for developing a blood clot in the spine. Fondaparinux has not been reported to cause thrombocytopenia, a condition seen with heparin. It is 100% bioavailable, with little or no protein binding.

Fondaparinux Supplier

Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Email
waley188@sohu.com