ETHYL 6-(TRIFLUOROMETHYL)-INDOLE-2-CARBOXYLATE Chemical Properties

storage temp. 

Sealed in dry,Room Temperature

Appearance

Off-white to light yellow Solid

ETHYL 6-(TRIFLUOROMETHYL)-INDOLE-2-CARBOXYLATE Usage And Synthesis

Synthesis

To a 1000 mL three-necked flask was added (E)-ethyl-2-(2-(3-(trifluoromethyl)phenyl)hydrazinyl)propionate (26 g, 94.8 mmol) synthesized in Step 1 and toluene. Subsequently, polyphosphoric acid (150 g) was slowly added to the reaction system, heated to reflux and maintained for 6 hours. After completion of the reaction, the reaction mixture was cooled to 50°C and the toluene layer was separated. The toluene layer was concentrated to dryness under reduced pressure. Toluene (50 mL) was added to the resulting solid, refluxed for 1 hour and cooled to room temperature. The recrystallized product was collected by filtration to afford ethyl 6-(trifluoromethyl)-1H-indole-2-carboxylate (1.25 g, 4.86 mmol, 5% yield).

References

[1] Patent: KR101741956, 2017, B1. Location in patent: Paragraph 0411; 0415-0417

ETHYL 6-(TRIFLUOROMETHYL)-INDOLE-2-CARBOXYLATE(327-21-9)Related Product Information

• 6-TRIFLUOROMETHYL-1H-INDOLE-2-CARBOXYLIC ACID
• 6-(TRIFLUOROMETHYL)-1H-INDAZOLE
• 6-(Trifluoromethyl)indole
• ETHYL 6-(TRIFLUOROMETHYL)-INDOLE-2-CARBOXYLATE