3-Cyanobenzenesulfonamide Chemical Properties

Melting point:

151-153°C

Boiling point:

392.5±44.0 °C(Predicted)

Density 

1.47±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

powder

pka

9.56±0.60(Predicted)

Appearance

Light brown to brown Solid

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

7/9-22-24/25-26-36/37-38-51

RIDADR 

UN3439

WGK Germany 

3

HazardClass 

6.1

PackingGroup 

III

HS Code 

2935909099

3-Cyanobenzenesulfonamide Usage And Synthesis

Synthesis

The general procedure for the synthesis of 3-cyanobenzenesulfonamide from 3-cyanobenzenesulfonyl chloride is as follows: an excess of ammonia (22 mL) was added to a solution of acetonitrile (22 mL) containing 3-cyanobenzenesulfonyl chloride (1.0 g, 4.97 mmol) and the reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the reaction mixture was concentrated and the resulting solid was washed with water to give 500 mg of product. The aqueous phase could be extracted with ethyl acetate, dried over anhydrous magnesium sulfate and filtered, and the solvent was evaporated to give 400 mg of product. This portion of the product was combined with the previously obtained solid to give a total yield of 0.90 g in 99% yield.

References

[1] Patent: WO2009/24585, 2009, A2. Location in patent: Page/Page column 77
[2] Patent: WO2009/80663, 2009, A1. Location in patent: Page/Page column 119
[3] Patent: US2006/173183, 2006, A1. Location in patent: Page/Page column 86
[4] Patent: WO2006/128184, 2006, A2. Location in patent: Page/Page column 160
[5] Patent: CN107098846, 2017, A. Location in patent: Paragraph 2475; 2477; 2478

3-Cyanobenzenesulfonamide(3118-68-1)Related Product Information

• 3-Cyanobenzenesulfonamide
• Benzenesulfonamide, 2-cyano- (9CI)
• 3-(Pyrrolidin-1-ylsulfonyl)benzonitrile
• Benzenesulfonamide, 4-cyano- (9CI)
• 3-(4-MORPHOLIN-4-YL-2-PHENYL-7,8-DIHYDRO-5H-PYRIDO[4,3-D]PYRIMIDINE-6-SULFONYL)-BENZONITRILE
• 3-(4-AZEPAN-1-YL-2-METHYL-7,8-DIHYDRO-5H-PYRIDO[4,3-D]PYRIMIDINE-6-SULFONYL)-BENZONITRILE
• 3-[(2-METHYL-4-PYRROLIDIN-1-YL-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDIN-6(5H)-YL)SULFONYL]BENZONITRILE
• 3-[(2-METHYL-4-MORPHOLIN-4-YL-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDIN-6(5H)-YL)SULFONYL]BENZONITRILE
• 3-(4-MORPHOLIN-4-YL-2-PYRIDIN-4-YL-7,8-DIHYDRO-5H-PYRIDO[4,3-D]PYRIMIDINE-6-SULFONYL)-BENZONITRILE
• [[(3-CYANOPHENYL)SULFONYL]AMINO]ACETIC ACID
• 3-(4-PIPERIDIN-1-YL-2-PYRIDIN-4-YL-7,8-DIHYDRO-5H-PYRIDO[4,3-D]PYRIMIDINE-6-SULFONYL)-BENZONITRILE
• 1-[6-(3-CYANO-BENZENESULFONYL)-2-PHENYL-5,6,7,8-TETRAHYDRO-PYRIDO[4,3-D]PYRIMIDIN-4-YL]-PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER
• 3-(piperidin-1-ylsulfonyl)benzonitrile
• 3-(2-METHYL-4-PIPERIDIN-1-YL-7,8-DIHYDRO-5H-PYRIDO[4,3-D]PYRIMIDINE-6-SULFONYL)-BENZONITRILE
• 3-(azepan-1-ylsulfonyl)benzonitrile
• 1-[6-(3-CYANO-BENZENESULFONYL)-2-METHYL-5,6,7,8-TETRAHYDRO-PYRIDO[4,3-D]PYRIMIDIN-4-YL]-PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER
• 3-(4-MORPHOLIN-4-YL-2-PYRIDIN-3-YL-7,8-DIHYDRO-5H-PYRIDO[4,3-D]PYRIMIDINE-6-SULFONYL)-BENZONITRILE
• 3-(2-PYRIDIN-4-YL-4-PYRROLIDIN-1-YL-7,8-DIHYDRO-5H-PYRIDO[4,3-D]PYRIMIDINE-6-SULFONYL)-BENZONITRILE