atamestane Chemical Properties

Melting point:

165-167 °C(Solv: ethyl ether (60-29-7); hexane (110-54-3))

Boiling point:

443.0±45.0 °C(Predicted)

Density 

1.12±0.1 g/cm3(Predicted)

EPA Substance Registry System

1-Methylandrosta-1,4-diene-3,17-dione (96301-34-7)

atamestane Usage And Synthesis

Originator

Atamestane,Schering AG

Manufacturing Process

6.01 g of 17β-hydroxy-1-methylandrosta-1,4-dien-3-one is dissolved in 100 ml of acetone. At room temperature, 22 ml of a chromic acid solution (prepared from 6.67 g of CrO3, 6 ml of concentrated sulfuric acid, replenished with water to 100 ml) is added dropwise to this solution. The mixture is stirred for one hour and then precipitated into ice water, the product is suctioned off and dried, thus obtaining after recrystallization from acetone/hexane 5.25 g of 1-methylandrosta-1,4-diene-3,17-dione, melting point 165-166°C.

Therapeutic Function

Aromatase inhibitor

atamestane(96301-34-7)Related Product Information

• Androsta-1,4-diene-3,17-dione
• atamestane