Atrolactamide Chemical Properties

Melting point:

62.5-63.5 °C(Solv: benzene (71-43-2))

Boiling point:

349.3±35.0 °C(Predicted)

Density 

1?+-.0.06 g/cm3(Predicted)

pka

12.53±0.29(Predicted)

Atrolactamide Usage And Synthesis

Uses

Atrolactamide (M-144) is a potent anticonvulsant. Atrolactamide can be used for the research of epilepsy[1].

Definition

ChEBI: Atrolactamide is a member of acetamides.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 46, p. 2494, 2003 DOI: 10.1021/jm020546r
Tetrahedron Letters, 21, p. 1219, 1980 DOI: 10.1016/S0040-4039(00)71375-X

References

[1] Schenck HA,et al. Design, synthesis and evaluation of novel hydroxyamides as orally available anticonvulsants. Bioorg Med Chem. 2004 Mar 1;12(5):979-93. DOI:10.1016/j.bmc.2003.12.011

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