Dexelvucitabine
Dexelvucitabine Basic information
- Product Name:
- Dexelvucitabine
- Synonyms:
-
- Dexelvucitabine
- 2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine
- 4-AMINO-5-FLUORO-1-[(2R,5S)-5-(HYDROXYMETHYL)-2,5-DIHYDROFURAN-2-YL]PYRIMIDIN-2(1H)-ONE
- Cytidine,2',3'-didehydro-2',3'-dideoxy-5-fluoro-
- INCB 8721
- RA 131423
- Reverset
- YZ 817
- CAS:
- 134379-77-4
- MF:
- C9H10FN3O3
- MW:
- 227.19
- Mol File:
- 134379-77-4.mol
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Dexelvucitabine Chemical Properties
- Boiling point:
- 394.9±52.0 °C(Predicted)
- Density
- 1.66±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:0.0(Max Conc. mg/mL);0.0(Max Conc. mM)
- form
- Solid
- pka
- 14.28±0.10(Predicted)
- color
- White to off-white
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Dexelvucitabine Usage And Synthesis
Uses
Treatment of HIV-1 and HIV-2 infection.
Uses
Dexelvucitabine is a nucleoside reverse transcriptase inhibitor (NRTI) which had the potential to inhibit HIV-1 replication. The drug was discontinued due to evidence that it causes damage to the pancreas.
brand name
Reverset (Incyte).
in vivo
Dexelvucitabine (Reverset; d-d4FC; 33.3 mg/kg by i.v. or p.o.) has distribution and elimination half-lives (t1/2α?and?t1/2β, respectively) of 0.7 and 3.6 h in monkeys, respectively. The Cmax ranges from 21.1 to 47.5 μM[2].
Dexelvucitabine has a favorable pharmacokinetic profile with a long half-life (4.71 and 10.75 h after administration by the intravenous [i.v.] and oral [p.o.] routes, respectively)?in woodchucks[2].
IC 50
HIV-1
DexelvucitabineSupplier
LGM Pharma
- Tel
- 1-(800)-881-8210
- inquiries@lgmpharma.com
Shanghai Fuhe Chemistry Technology Co., Ltd.
- Tel
- 0086-21-67651709
- cfx759@hotmail.com
T&W GROUP
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- 021-61551611 13296011611
- contact@trustwe.com
Zhengzhou GranLen pharmaceutical Technology Co., Ltd.
- Tel
- 0371-85513397
- info@granlen.com
Amadis Chemical Company Limited
- Tel
- 571-89925085
- sales@amadischem.com