Pyridindolol
Pyridindolol Basic information
- Product Name:
- Pyridindolol
- Synonyms:
-
- Pyridindolol
- (R)-α-Hydroxymethyl-9H-pyrido[3,4-b]indole-1,3-dimethanol
- 1-[(1R)-1,2-Dihydroxyethyl]-9H-pyrido[3,4-b]indole-3-methanol
- 1-[3-(HYDROXYMETHYL)-9H-PYRIDO[3,4-B]INDOL-1-YL]ETHANE-1,2-DIOL
- 9H-Pyrido[3,4-b]indole-1,3-dimethanol, α1-(hydroxymethyl)-, (α1R)-
- CAS:
- 55812-46-9
- MF:
- C14H14N2O3
- MW:
- 258.27
- Mol File:
- 55812-46-9.mol
Pyridindolol Chemical Properties
- storage temp.
- -20°C
- form
- A crystalline solid
Pyridindolol Usage And Synthesis
Biological Activity
Pyrindolol is a bacterial metabolite that has been found in S. alboverticillatus.1 It inhibits neutral β-galactosidase by 50% under acidic, but not neutral, conditions when used at a concentration of 2 μg/ml. It is selective for β-galactosidase isolated from bovine liver over β-galactosidases isolated from human, bovine, pig, and rat tissues and sialidases isolated from C. perfringens, Streptomyces, and the H3N2 strain of influenza virus (IC50s = >250 μg/ml for all).1,2
References
1.Aoyagi, T., Kumagai, M., Hazato, T., et al.Pyridindolol, a new β-galactosidase inhibitor produced by actinomycetesJ. Antibiot. (Tokyo)28(7)555-557(1975) 2.Kumagai, M., Aoyagi, T., and Umezawa, H.Inhibitory activity of pyridindolol on β-galactosidaseJ. Antibiot. (Tokyo)29(7)696-703(1976)