Zoloperone
Zoloperone Basic information
- Product Name:
- Zoloperone
- Synonyms:
-
- 4-(4-Fluorophenyl)-5-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-4-oxazolin-2-one
- 4-(4-Fluorophenyl)-5-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]oxazol-2(3H)-one
- 4-(4-fluorophenyl)-5-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)oxazol-2(3H)-one
- Zoloperone
- LR 511
- 2(3H)-Oxazolone, 4-(4-fluorophenyl)-5-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-
- Zoloperonum
- CAS:
- 52867-74-0
- MF:
- C22H24FN3O3
- MW:
- 397.448
- Mol File:
- 52867-74-0.mol
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Zoloperone Usage And Synthesis
Originator
Zoloperone,ZYF Pharm Chemical
Manufacturing Process
To 20% solution of phosgene in toluene, agitated and cooled to 0°C, are added over 30 min a solution of 1-p-fluoro-benzoyl-1-hydroxy-3-N-[N'-(2- methoxyphenyl)]piperazinopropane and triethylamine in anhydrous chloroform. It is agitated at ambient temperature for 5 h, cooled to 0°C and the solution saturated with gaseous ammonia. The solution is agitated at ambient temperature for 3 h, filtered and the filtrate dried under reduced pressure, 4-ρ-fluorophenyl-5-β-(4-o-methoxyphenylpiperazino)ethyl-4- oxazolin-2-one, melting point 154°C (by alcohol) was obtained.
Therapeutic Function
Neuroleptic