Methyl p-nitrophenylacetate Chemical Properties

Melting point:

52.4-53.3 °C

Boiling point:

308.6±17.0 °C(Predicted)

Density 

1.266±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

solid

color 

Off-white

Safety Information

HS Code 

2915390090

Methyl p-nitrophenylacetate Usage And Synthesis

Appearance

a pale orange oil

Synthesis

4-nitrophenylacetic acid(2.00 g, 11 mmol) was added to a clean carousel tube. Dimethyl carbonate (3 mL, 3.21 g, 35.6 mmol) was added, and the reaction was heated at reflux overnight. The brown solution was allowed to cool, and poured in to aqueous sodium bicarbonate (10%, 10 mL) while stirring. The resulting mixture was extracted with ethyl acetate (3 x 10 mL). The combined organic layers were washed with water and brine (10 mL each), and dried over anhydrous magnesium sulphate. After filtration and evaporation of the solvents, proton NMR analysis showed the product had formed, and none of the precursor acid remained. No further purification was performed. This gave methyl p-nitrophenylacetate as a pale orange oil (1.929 g, 9.89 mmol, 90%)): 1H NMR (400 MHz, CDCl 3 ) |? 8.20 (d, J = 8.6 Hz, 2H), 7.46 (d, J = 8.6 Hz, 2H, 3.74 (s, 2H), 3.73 (s, 3H).

Methyl p-nitrophenylacetate(2945-08-6)Related Product Information

• METHYL PENTAFLUOROBENZOATE
• METHYL 4-AMINOSALICYLATE
• METHYL 3-(4-METHOXYPHENYL)PROPIONATE
• Methyl p-nitrophenylacetate
• BIS(2,4-DINITROPHENYL)ACETIC ACID ETHYL ESTER
• METHYL 2,4-DINITROPHENYLACETATE
• Ethyl 4-nitrophenylacetate
• ETHYL 4-NITROPHENYLGLYOXYLATE
• 4-Nitrophenylacetic acid
• 6-CHLORO-4-METHYL-3-(4'-NITROPHENYL)COUMARIN
• DIMETHYL 2-METHYL-2-(4-NITROPHENYL)MALONATE
• 2-DIETHYLAMINOETHYL 1-(4-NITROPHENYL)CYCLOPENTANECARBOXYLATE HYDROCHLORIDE
• methyl 2-(4-nitrophenyl)propionate
• 6-METHOXY-3(4'-NITROPHENYL)COUMARIN
• 3(4'-NITROPHENYL)COUMARIN
• DIMETHYL 2-(2,4-DINITROPHENYL)MALONATE
• 2-OXOPROPYL 2-(4-NITROPHENYL)ACETATE
• 5-[(DIMETHYLAMINO)METHYLENE]-4-METHYL-3-(4-NITROPHENYL)-2(5H)-FURANONE