6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chloroph enyl)-1-methyl-quinolin-2-one
6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chloroph enyl)-1-methyl-quinolin-2-one Basic information
- Product Name:
- 6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chloroph enyl)-1-methyl-quinolin-2-one
- Synonyms:
-
- 6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chloroph enyl)-1-methyl-quinolin-2-one
- 2(1H)-Quinolinone, 6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-
- CAS:
- 192185-68-5
- MF:
- C27H22Cl2N4O
- MW:
- 489.4
- Mol File:
- 192185-68-5.mol
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6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chloroph enyl)-1-methyl-quinolin-2-one Chemical Properties
- Melting point:
- 214 °C(Solv: acetonitrile (75-05-8); dichloromethane (75-09-2); methanol (67-56-1))
- Boiling point:
- 681.7±55.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- pka
- 7.20±0.10(Predicted)
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6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chloroph enyl)-1-methyl-quinolin-2-one Usage And Synthesis
Description
R 115777 is a farnesyl transferase inhibitor.
Uses
(Rac)-Tipifarnib ((Rac)-IND 58359; (Rac)-R115777) is a potent farnesyl protein transferase inhibitor that specifically targets the pro-tailation process of Ras proteins. (Rac)-Tipifarnib showed significant in vivo antitumor effects after oral administration to mice[1].
References
[1] Venet M, et al. Farnesyl protein transferase inhibitor ZARNESTRA R115777-History of a discovery[J]. Current Topics in Medicinal Chemistry, 2003, 3(10): 1095-1102.