FR 75513
FR 75513 Basic information
- Product Name:
- FR 75513
- Synonyms:
-
- FR 75513
- 6-(1-Methylethyl) 2-methyl 3-hydroxy-5-methyl-2'-nitro-(1,1'-biphenyl)-2,6-dicarboxylate
- 3-Hydroxy-5-methyl-2'-nitro-1,1'-biphenyl-2,6-dicarboxylic acid 2-methyl 6-isopropyl ester
- [1,1'-Biphenyl]-2,6-dicarboxylic acid, 3-hydroxy-5-methyl-2'-nitro-, 2-methyl 6-(1-methylethyl) ester
- CAS:
- 127975-78-4
- MF:
- C19H19NO7
- MW:
- 373.36
- Mol File:
- 127975-78-4.mol
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FR 75513 Chemical Properties
- Boiling point:
- 523.5±50.0 °C(Predicted)
- Density
- 1.285±0.06 g/cm3(Predicted)
- pka
- 7.87±0.30(Predicted)
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FR 75513 Usage And Synthesis
Description
FR 75513 has inhibitory activity on guinea pig detrusor muscle contraction.
Uses
FR 75513 is a 1,1'-biphenyl-2,6-dicarboxylic acid diester series compound that can inhibit the contraction of the detrusor muscle of guinea pig bladder (IC50=3.3 μg/mL). After intravenous injection of FR 75513 into anesthetized rats, it also showed strong inhibitory activity on the detrusor contraction (ID50=0.04 mg/kg).
References
[1] Agents for the Treatment of Overactive Detrusor. I. Synthesis and Structure-Activity Relationships of 1, 1'-Biphenyl Derivatives