NPC 17731 Chemical Properties

Sequence

Arg-Arg-Pro-{Hyp}-Gly-Phe-Ser-{Hyp}-{Oic}-Arg

NPC 17731 Usage And Synthesis

Description

NPC 17731 is a bradykinin receptor antagonist.

Uses

NPC 17731 is a new bradykinin (BK) receptor antagonist. NPC 17731 antagonized both the contractile and relaxant responses caused by BK in longitudinal smooth muscle with IC50 of 23 and 29 nM, respectively[1].

References

[1] Y S Medeiros, et al. Competitive and selective antagonistic action of NPC 17731 on bradykinin-induced relaxant and contractile responses of the guinea pig isolated ileum. Gen Pharmacol. 1995 Nov;26(7):1507-11. DOI:10.1016/0306-3623(95)00031-3