L 657925
L 657925 Basic information
- Product Name:
- L 657925
- Synonyms:
-
- L 657925
- (-)-9-(4-Chlorobenzyl)-6-fluoro-2,3,4,4a,9,9a-hexahydro-1H-carbazole-1-acetic acid
- 1H-Carbazole-1-acetic acid, 9-[(4-chlorophenyl)methyl]-6-fluoro-2,3,4,4a,9,9a-hexahydro-, (-)-
- CAS:
- 122757-59-9
- MF:
- C21H21ClFNO2
- MW:
- 373.85
- Mol File:
- 122757-59-9.mol
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L 657925 Usage And Synthesis
Description
L 657925 is a thromboxane A2 receptor antagonist.
Uses
L 657925 is a potent thromboxane A2 (TXA2) antagonist. L 657925 selectively abolishes ONO 11113-evoked transient increment in [Ca22+][1].
IC 50
TXA2
References
[1] Ueda N, et al. Receptor-mediated increase in cytosolic calcium in LLC-PK1 cells by platelet activating factor and thromboxane A2. Kidney Int. 1991 Dec;40(6):1075-81. DOI:10.1038/ki.1991.317