LY 206130
LY 206130 Basic information
- Product Name:
- LY 206130
- Synonyms:
-
- LY 206130
- 1-(cyclohexylamino)-3-(1H-indol-4-yloxy)propan-2-ol
- 2-Propanol, 1-(cyclohexylamino)-3-(1H-indol-4-yloxy)-
- CAS:
- 127414-58-8
- MF:
- C17H24N2O2
- MW:
- 288.38
- Mol File:
- 127414-58-8.mol
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LY 206130 Chemical Properties
- Boiling point:
- 521.5±40.0 °C(Predicted)
- Density
- 1.17±0.1 g/cm3(Predicted)
- pka
- 13.95±0.20(Predicted)
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LY 206130 Usage And Synthesis
Description
LY 206130 is a serotonin 5-HT1A antagonist.
Uses
LY206130 free base is a 5-HT1A receptor antagonist with the activity of enhancing exogenous serotonin levels. LY206130 free base, when used concomitantly with fluoxetine, may enhance the appetite-suppressing effects of fluoxetine. LY206130 free base was shown to significantly reduce sweetened milk concentrate consumption in a dietary model. Clinical application of LY206130 free base may be beneficial in curbing eating disorders and obesity[1].
References
[1] 5HT1A receptor antagonists enhance the functional activity of fluoxetine in a mouse model of feeding