gemcitabine Chemical Properties

Boiling point:

482.7±55.0 °C(Predicted)

Density 

1.4034 (estimate)

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

11.65±0.70(Predicted)

color 

White

gemcitabine Usage And Synthesis

Uses

Gemcitabine is a nucleoside analog with anti-cancer properties. An inhibitor of DNA synthesis active on solid tumors.

Definition

ChEBI: Gemcitabine is a 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer. It has a role as a photosensitizing agent, a DNA synthesis inhibitor, a prodrug, an EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor, an environmental contaminant, a xenobiotic, a radiosensitizing agent, an antineoplastic agent, an antimetabolite, an antiviral drug and an immunosuppressive agent. It is an organofluorine compound and a pyrimidine 2'-deoxyribonucleoside.

gemcitabine(103882-84-4)Related Product Information

• 2',2'-Difluoro-2'-deoxycytidine-3',5'-dibenzoate
• Gemcitabine hydrochloride
• GEMCITABINE, [5-3H]-
• 2'-DEOXY-3',5'-DI-O-BENZOYL-2',2'-DIFLUOROCYTIDINE-13C,15N2
• gemcitabine
• DTBS-GEMCITABINE