cyclothialidine
cyclothialidine Basic information
- Product Name:
- cyclothialidine
- Synonyms:
-
- cyclothialidine
- L-Alanine, L-seryl-(3R)-3-hydroxy-L-prolyl-O-[3,5-dihydroxy-2-(mercaptomethyl)-6-methylbenzoyl]-L-seryl-L-cysteinyl-, cyclic (3→4)-thioether
- Ro 09-1437
- CAS:
- 147214-63-9
- MF:
- C26H35N5O12S
- MW:
- 641.65
- Mol File:
- 147214-63-9.mol
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cyclothialidine Chemical Properties
- Boiling point:
- 1253.4±65.0 °C(Predicted)
- Density
- 1.60±0.1 g/cm3(Predicted)
- pka
- 3.61±0.10(Predicted)
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cyclothialidine Usage And Synthesis
Uses
Cyclothialidine ( Ro 09-1437) is a potent DNA gyrase inhibitor isolated from Streptomyces filipinensisNR0484[1].
References
[1] Angehrn P, et al. New antibacterial agents derived from the DNA gyrase inhibitor cyclothialidine. J Med Chem. 2004;47(6):1487-1513. DOI:10.1021/jm0310232
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