cannabidiolic acid
cannabidiolic acid Basic information
- Product Name:
- cannabidiolic acid
- Synonyms:
-
- cannabidiolic acid
- 2,4-Dihydroxy-3-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-6-pentylbenzoic acid
- 2,4-Dihydroxy-3-[(1R,6R)-3-methyl-6-isopropenyl-2-cyclohexenyl]-6-pentylbenzoic acid
- 2,4-dihydroxy-3-[(1R,6R)-3-methyl-6-prop-1-en-2-yl-cyclohex-2-en-1-yl]-6-pentyl-benzoic acid
- 2,4-dihydroxy-3-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]-6-pentylbenzoic acid
- 6-amyl-2,4-dihydroxy-3-[(1R,6R)-6-isopropenyl-3-methyl-cyclohex-2-en-1-yl]benzoic acid
- Cannabidiolic Acid (CRM)
- Cannabidiolic acid solution
- CAS:
- 1244-58-2
- MF:
- C22H30O4
- MW:
- 358.47
- Mol File:
- 1244-58-2.mol
cannabidiolic acid Chemical Properties
- Melting point:
- 45-48 °C
- Boiling point:
- 530.8±50.0 °C(Predicted)
- Density
- 1.123±0.06 g/cm3(Predicted)
- Flash point:
- 2℃
- storage temp.
- −20°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- pka
- 3.41±0.43(Predicted)
- LogP
- 7.870 (est)
cannabidiolic acid Usage And Synthesis
Description
Cannabidiolic acid (Item No. 18090) is a certified reference material categorized as a phytocannabinoid. Cannabidiolic acid is produced by the oxidocyclization of cannabigerolic acid (Item Nos. 20019 | 9001574) by cannabidiolic acid synthase. This product is intended for research and forensic applications.
Uses
Cannabidiolic Acid is a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration. Cannabidiolic Acid offers potential therapeutic value in the abrogation of cancer cell migration and aggressive breast cancers.
Definition
ChEBI: A dihydroxybenzoic acid that is olivetolic acid in which the hydrogen at position 3 is substituted by a 3-p-mentha-1,8-dien-3-yl (limonene) group.
target
cAMP | COX | 5-HT Receptor
References
[1] F TAURA Y S S Morimoto. Purification and characterization of cannabidiolic-acid synthase from Cannabis sativa L.. Biochemical analysis of a novel enzyme that catalyzes the oxidocyclization of cannabigerolic acid to cannabidiolic acid.[J]. The Journal of Biological Chemistry, 1996, 271 29: 17411-17416. DOI: 10.1074/jbc.271.29.17411
[2] AYAT ZAGZOOG. In vitro and in vivo pharmacological activity of minor cannabinoids isolated from Cannabis sativa.[J]. Scientific Reports, 2020: 20405. DOI: 10.1038/s41598-020-77175-y
[3] DANIELE VIGLI. Chronic Treatment with Cannabidiolic Acid (CBDA) Reduces Thermal Pain Sensitivity in Male Mice and Rescues the Hyperalgesia in a Mouse Model of Rett Syndrome[J]. Neuroscience, 2021, 453: Pages 113-123. DOI: 10.1016/j.neuroscience.2020.09.041