ICI 153110
ICI 153110 Basic information
- Product Name:
- ICI 153110
- Synonyms:
-
- ICI 153110
- 4,5-Dihydro-6-[(E)-2-(4-pyridinyl)ethenyl]-2H-pyridazin-3-one
- 3(2H)-Pyridazinone, 4,5-dihydro-6-[(1E)-2-(4-pyridinyl)ethenyl]-
- (E)-4,5-Dihydro-6-(2-(4-pyridinyl)ethenyl)-3(2H)-pyridazinone
- CAS:
- 87164-90-7
- MF:
- C11H11N3O
- MW:
- 201.22
- Mol File:
- 87164-90-7.mol
ICI 153110 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
ICI 153110 Usage And Synthesis
Uses
ICI 153110 is an orally active phosphodiesterase inhibitor with both vasodilating and inotropic properties which is designed for the treatment of congestive cardiac failure.
in vivo
ICI 153110 is an orally active phosphodiesterase inhibitor with both vasodilating and inotropic properties which is designed for the treatment of congestive cardiac failure. Fourteen animals have died as a direct or indirect consequence of ICI 153110 administration in the high-dose main test and reversibility groups. In the female rat dosed at 10 mg/kg/day ICI 153110 a mild focal arteritis is characterized by a predominantly and diffusely adventitial infiltration of mixed cells and early formation of fibrous tissue. The two rats dosed at 250 mg/kg/day ICI 153110 die prematurely from intratracheal intubation of dosing solution. Arteries from two further animals (dosed at 5 and 250 mg/kg/day ICI 153110) show minimal focal arteritis with medial necrosis, and medial and adventitial inflammation[1].
References
[1] Westwood FR, et al. Pathologic changes in blood vessels following administration of an inotropic vasodilator (ICI 153,110) to the rat. Fundam Appl Toxicol. 1990 May;14(4):797-809. DOI:10.1016/0272-0590(90)90304-3
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