PNU 103017
PNU 103017 Basic information
- Product Name:
- PNU 103017
- Synonyms:
-
- PNU 103017
- Benzenesulfonamide, 4-cyano-N-[3-[cyclopropyl(5,6,7,8,9,10-hexahydro-4-hydroxy-2-oxo-2H-cycloocta[b]pyran-3-yl)methyl]phenyl]-
- PNU103017,PNU 103017
- CAS:
- 166335-18-8
- MF:
- C28H28N2O5S
- MW:
- 504.6
- Mol File:
- 166335-18-8.mol
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PNU 103017 Chemical Properties
- Boiling point:
- 721.3±70.0 °C(Predicted)
- Density
- 1.39±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 4.50±1.00(Predicted)
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PNU 103017 Usage And Synthesis
Uses
PNU-103017 is an HIV protease inhibitor.
in vivo
PNU-103017 is a selective HIV aspartyl protease inhibitor under evaluation as a potential oral treatment of Acquired Immunodeficiency Diseases. PNU-103017 is a racemic mixture of two enantiomers, designated PNU-103264 (R-) and PNU-103265 (S-). The Cmax (P≤0.0349), Cmin (P≤0.0168), and Cav (P≤0.0118) are significantly higher for the (R)- than the (S)-enantiomer, showing enantioselective pharmacokinetics of PNU-103017 in the dog[1].
References
[1] Williams MG, et al. Stereospecific determination of an HIV aspartyl protease inhibitor, PNU-103017, in rat, dog and human plasma using a Pirkle-concept high-performance liquid chromatographic column. DOI:10.1016/s0378-4347(97)00121-7
PNU 103017Supplier
Fan De(Beijing) Biotechnology Co., Ltd.
- Tel
- 15911056312
- liming@bio-fount.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
cjbscvictory
- Tel
- 13348960310
- 3003867561@qq.com
Beijing Jin Ming Biotechnology Co., Ltd.
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
TargetMol Chemicals Inc.
- Tel
- 4008200310
- marketing@tsbiochem.com