3-(2-Thienyl)-1-propanol Chemical Properties

Boiling point:

240℃

Density 

1.131

Flash point:

99℃

storage temp. 

2-8°C(protect from light)

pka

15.03±0.10(Predicted)

Appearance

Colorless to light yellow Liquid

Safety Information

HS Code 

2934999090

3-(2-Thienyl)-1-propanol Usage And Synthesis

Synthesis Reference(s)

The Journal of Organic Chemistry, 36, p. 2236, 1971 DOI: 10.1021/jo00815a008

Synthesis

Step 1: Borane methyl sulfide complex (6.4 mL, 12.8 mmol) was slowly added to a solution of 3-(2-thienyl)propionic acid (1.0 g, 6.4 mmol) in tetrahydrofuran (THF, 18 mL), keeping the reaction temperature at 0 °C. The reaction mixture was stirred continuously at 0 °C for 2 h, and then brought to room temperature and continued stirring for 3 h. The reaction mixture was then cooled to room temperature. Upon completion of the reaction, the mixture was cooled to 0 °C and saturated potassium carbonate solution (5 mL) was slowly added to quench the reaction. The aqueous layer was separated and the organic phase was extracted with ethyl acetate (2 x 15 mL) and ether (2 x 15 mL), respectively. All organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated to dryness under reduced pressure to afford the target product 3-(2-thienyl)-1-propanol as a colorless oil (1.0 g, 100% yield). The product was characterized by 1H NMR (CDCl3, 400 MHz): δ 7.18-7.17 (m, 1H), 6.99-6.96 (m, 1H), 6.87-6.86 (m, 1H), 3.79-3.74 (m, 2H), 3.0 (t, J = 7.6 Hz, 2H), 2.4-1.97 (m, 2H).

References

[1] Patent: WO2011/61214, 2011, A1. Location in patent: Page/Page column 87-88
[2] Patent: WO2008/79382, 2008, A1. Location in patent: Page/Page column 128
[3] Journal of the American Chemical Society, 2015, vol. 137, # 32, p. 10100 - 10103
[4] Patent: US6218538, 2001, B1

3-(2-Thienyl)-1-propanol(19498-72-7)Related Product Information

• BOC-D-2-THIENYLALANINE
• BETA-(2-THIENYL)-DL-ALANINE
• 3-(2-THIENYL)PROPIONIC ACID
• D-2-THIENYLALANINE
• L-2-THIENYLALANINE
• (S)-N-FMOC-2-Thienylalanine
• BETA-(2-THIENYL)-DL-SERINE
• 7-DIETHYLAMINO-3-THENOYLCOUMARIN
• Boc-3-(2-thienyl)-L-alanine
• 7-OXO-4,7-DIHYDRO-THIENO[3,2-B]PYRIDINE-6-CARBOXYLIC ACID ETHYL ESTER
• 6-METHYL-2-OXO-4-THIOPHEN-2-YL-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
• 3-OXO-2-(THIOPHENE-2-CARBONYL)-BUTYRIC ACID ETHYL ESTER
• 7-Hydroxy-thieno[3,2-b]pyridine- 6-carboxylic acid
• DL-3-(2-thienyl)-beta-alanine
• FMOC-D-2-THIENYLALANINE
• METHYL 3-[(2-METHOXY-2-OXOETHYL)THIO]-3-(2-THIENYL)PROPANOATE
• 3-(2-THIENYL)-L-SERINE MONOHYDRATE
• DIETHYL THENYL MALONATE