(4-FLUORO-3-NITROPHENYL)ACETONITRILE Chemical Properties

storage temp. 

Sealed in dry,Room Temperature

Appearance

Light yellow to yellow Solid

Safety Information

HS Code 

2926907090

(4-FLUORO-3-NITROPHENYL)ACETONITRILE Usage And Synthesis

Application

(4-Fluoro-3-Nitrophenyl)Acetonitrile is a useful research chemical compound.

Synthesis

34A: Synthesis of 2-(4-fluoro-3-nitrophenyl)acetonitrile To a solution of 4-(bromomethyl)-1-fluoro-2-nitrobenzene (1 g, 4.27 mmol) in acetonitrile (5 mL) was added tetraethylammonium cyanide (0.801 g, 5.13 mmol). The reaction mixture was stirred at room temperature for 4 h. The reaction solution was dark green in color. After completion of the reaction, the solvent was removed by rotary evaporator under reduced pressure. The crude product was purified by fast column chromatography to afford 34A (light yellow oil, 617 mg, 3.43 mmol, 80% yield).LC-MS analysis: calculated value of C8H5F2O2 was 180.03, no parent ion was observed, retention time (Tr) = 0.74 min (Method B).

References

[1] Patent: WO2014/150646, 2014, A1. Location in patent: Page/Page column 76; 77
[2] Journal of the Chemical Society - Series Chemical Communications, 1994, # 4, p. 439 - 440

(4-FLUORO-3-NITROPHENYL)ACETONITRILE(157662-77-6)Related Product Information

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