ETHYL 1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLATE Chemical Properties

Melting point:

27 °C

Boiling point:

380.6±30.0 °C(Predicted)

Density 

1.13±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

0.04±0.10(Predicted)

Safety Information

Hazard Note 

Harmful

HS Code 

2933199090

ETHYL 1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLATE Usage And Synthesis

Synthesis

To a solution of ethyl 2,4-dioxo-4-phenylbutyrate (1.0 g, 4.5 mmol), methylhydrazine sulfate (1.0 g, 6.8 mmol) and sodium hydroxide (0.5 g, 13.6 mmol) in ethanol (50 mL) was added the reaction mixture. The reaction mixture was stirred at 70 °C overnight. After completion of the reaction, the reaction was quenched with ice water (100 mL), extracted with ethyl acetate, the organic phase was washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated to give the crude product. The crude product was purified by silica gel column chromatography eluting with appropriate eluent to give ethyl 1-methyl-3-phenyl-1H-pyrazole-5-carboxylate (247.5 mg, 23.9%). Mass spectrum (ESI) m/z: 231.1 [M + 1].

References

[1] Patent: US2018/271846, 2018, A1. Location in patent: Paragraph 0176; 0178; 0179

ETHYL 1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLATE(10250-63-2)Related Product Information

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