Tanespimycin-d5
Tanespimycin-d5 Basic information
- Product Name:
- Tanespimycin-d5
- Synonyms:
-
- 17-(Allylamino-d5) Geldanamycin
- 17-(Allylamino-d5)-17-demethoxygeldanamycin
- 17-(Allylamino-d5)-17-desmethylgeldanamycin
- 17AAG-d5
- 17-Demethoxy-17-(2-propenylamino-d5)geldanamycin
- 17-Demethoxy-17-(allylamino-d5)geldanamycin
- CP 127374-d5
- KOS 953-d5
- MF:
- C31H43N3O8
- MW:
- 585.68842
- Product Categories:
-
- Amines
- Heterocycles
- Inhibitors
- Intermediates & Fine Chemicals
- Isotope Labeled Compounds
- Pharmaceuticals
- Isotope Labelled Compounds
- Mol File:
- Mol File
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Tanespimycin-d5 Chemical Properties
- Melting point:
- 161-163°C
- storage temp.
- -20°C Freezer, Under Inert Atmosphere
- solubility
- DMSO, Methanol
- form
- Solid
- color
- Dark Purple
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Tanespimycin-d5 Usage And Synthesis
Chemical Properties
Dark Solid
Uses
Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2.