9-OXO-15S-HYDROXY-PROSTA-5Z,10,13E,17Z-TETRAEN-1-OIC ACID Chemical Properties

storage temp. 

-20°C

solubility 

DMF: >75 mg/ml (from PGA1); DMSO: >50 mg/ml (from PGA1); Ethanol: >100 mg/ml (from PGA1); PBS pH 7.2: >2.4 mg/ml (from PGA1)

9-OXO-15S-HYDROXY-PROSTA-5Z,10,13E,17Z-TETRAEN-1-OIC ACID Usage And Synthesis

Description

Cyclooxygenase metabolism of EPA to produce Prostaglandin E₃ (PGE₃) has been reported in biosynthetic preparations of ovine seminal vesicles and in the ocular tissues of primates. Prostaglandin A₃ (PGA₃) is an expected non-enzymatic dehydration product of this PGE₃. PGA₃ exhibits good affinity for the canine EP₂ and EP₄ receptors with IC₅₀ values of 120 nM and 20 nM, respectively, in a radioligand binding assay. PGA₃ has weak affinity for human PPARγ, with a K_i value of 188 μM.

Definition

ChEBI: Prostaglandin A3 is a member of the class of prostaglandins A that is prosta-5,10,13,17-tetraen-1-oic acid carrying oxo and hydroxy substituents at positions 9 and 15 respectively (the 5Z,13E,15S,17Z-stereoisomer). It has a role as a mammalian metabolite. It is a prostaglandins A and a secondary allylic alcohol. It is a conjugate acid of a prostaglandin A3(1-).

9-OXO-15S-HYDROXY-PROSTA-5Z,10,13E,17Z-TETRAEN-1-OIC ACID(36614-31-0)Related Product Information

• 2-Cyclopenten-1-one
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