4-AMINO-N,N-DIMETHYLBENZAMIDE Chemical Properties

Melting point:

151-154°C

Boiling point:

348.0±25.0 °C(Predicted)

Density 

1.116±0.06 g/cm3 (20 ºC 760 Torr)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

2.66±0.10(Predicted)

form 

powder

color 

Light grey

Water Solubility 

Very soluble in water.

CAS DataBase Reference

6331-71-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

HazardClass 

IRRITANT

HS Code 

2921420090

MSDS

• Language:English Provider:ALFA

4-AMINO-N,N-DIMETHYLBENZAMIDE Usage And Synthesis

Uses

4-Amino-N,N-dimethylbenzamide is an important raw material and intermediate used in pharmaceuticals, agro based and dye stuff fields.

Synthesis

Step 2: Synthesis of 4-amino-N,N-dimethylbenzamide (Intermediate 74) Tert-butyl 4-(dimethylcarbamoyl)phenylcarbamate (Int.73, 1.11 g, 4.21 mmol) was dissolved in ethyl acetate (20 ml) to which ethyl acetate solution (18 ml, 76 mmol) of 4M HCl was added. The reaction mixture was stirred at room temperature for 5 hours. After completion of the reaction, the pH was adjusted to 6-7 with saturated NaHCO3 solution.The aqueous phase was extracted with ethyl acetate (3 x 20 ml). The organic phases were combined, dried over anhydrous Na2SO4 and concentrated under reduced pressure to give 615 mg of the title product (Int.74).

References

[1] Patent: US2011/280808, 2011, A1. Location in patent: Page/Page column 52
[2] Patent: US2013/324501, 2013, A1. Location in patent: Paragraph 0337; 0339
[3] Patent: WO2013/182451, 2013, A1. Location in patent: Page/Page column 90-91

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