7-bromo-4-chloro-3-nitroquinoline Chemical Properties

Boiling point:

387.6±37.0 °C(Predicted)

Density 

1.834±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

pka

-1.84±0.38(Predicted)

Appearance

White to light yellow Solid

InChI

InChI=1S/C9H4BrClN2O2/c10-5-1-2-6-7(3-5)12-4-8(9(6)11)13(14)15/h1-4H

InChIKey

KGTVATADCQABRD-UHFFFAOYSA-N

SMILES

N1C2C(=CC=C(Br)C=2)C(Cl)=C([N+]([O-])=O)C=1

7-bromo-4-chloro-3-nitroquinoline Usage And Synthesis

Synthesis

General procedure for the synthesis of 7-bromo-4-chloro-3-nitroquinolin-4-ol from 7-bromo-3-nitroquinolin-4-ol: 7-bromo-3-nitroquinolin-4-ol (3.8 g, 14.12 mmol) was suspended in phosphorous trichloride (20 mL) and anhydrous N,N-dimethylformamide (1 mL) was added. The reaction mixture was heated to 120 °C and maintained for 3 h under nitrogen protection. After completion of the reaction, it was cooled to room temperature. The precipitate was collected by filtration, washed with water and subsequently partitioned between dichloromethane (60 mL) and saturated aqueous sodium carbonate solution. The organic layer was separated, washed with saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated to give 7-bromo-4-chloro-3-nitroquinoline (3.3 g, 11.5 mmol, 81%) as a beige solid. Mass spectrum (electrospray ionization, m/z): [M + H]+ = 287.1 / 288.9.

References

[1] Patent: WO2017/184746, 2017, A1. Location in patent: Page/Page column 104; 105; 106
[2] Patent: WO2018/152396, 2018, A1. Location in patent: Page/Page column 147-148
[3] Patent: WO2004/58759, 2004, A1. Location in patent: Page 67
[4] Patent: WO2005/48945, 2005, A2. Location in patent: Page/Page column 159
[5] Patent: WO2005/48933, 2005, A2. Location in patent: Page/Page column 196

7-bromo-4-chloro-3-nitroquinoline(723280-98-6)Related Product Information

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