5-(4-CHLOROPHENYL)-2-FURALDEHYDE Chemical Properties

Melting point:

128-131 °C (lit.)

Boiling point:

350.7±32.0 °C(Predicted)

Density 

1.282±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

Needles

color 

Pale brown

CAS DataBase Reference

34035-03-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29321900

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

5-(4-CHLOROPHENYL)-2-FURALDEHYDE Usage And Synthesis

Chemical Properties

Pale brown needles

Uses

5-(4-Chlorophenyl)furfural is a metabolite of Azimilide (A926950, 2 HCl); an oral type III potassium channel blocker agent that blocks both the rapid activating component and the slow activating component of the delayed rectifier potassium current. Both preclinical and clinical studies have demonstrated the efficacy of Azimilide and its safety in the treatment of supraventricular and ventricular tachyarrhythmia. Azimilide is also being studied in a worldwide multicenter trial for prevention of sudden cardiac death in patients after myocardial infarction.

Uses

5-(4-Chlorophenyl)furfural was used as one of the aldehydes in the synthesis of uridine-based library.

General Description

5-(4-Chlorophenyl)furfural is a furfural derivative.

Synthesis

The target compounds 5-(4-chlorophenyl)-2-furancarboxaldehyde (1-9) were synthesized using 2-furancarboxaldehyde and 4-chloroaniline as starting materials and the reaction was carried out with reference to the methodology reported in the literature [3,13] and the structures were confirmed by appropriate characterization means.

References

[1] Heterocyclic Communications, 2003, vol. 9, # 6, p. 625 - 628
[2] Synthetic Communications, 2005, vol. 35, # 3, p. 333 - 340
[3] Asian Journal of Chemistry, 2013, vol. 25, # 14, p. 7738 - 7742
[4] Asian Journal of Chemistry, 2017, vol. 29, # 4, p. 735 - 741
[5] Russian Journal of Organic Chemistry, 2009, vol. 45, # 9, p. 1375 - 1381

5-(4-CHLOROPHENYL)-2-FURALDEHYDE(34035-03-5)Related Product Information

• 5-(2 4-DICHLOROPHENYL)FURFURAL 97
• 5-(4-CHLOROPHENYL)-2-FURALDEHYDE
• 5-(3 4-DICHLOROPHENYL)FURFURAL 97
• 5-(2-CHLOROPHENYL)-2-FURALDEHYDE
• 5-(3-CHLOROPHENYL)-2-FURALDEHYDE
• Furfural
• 5-(4-CHLOROPHENYL)-2-FUROIC ACID
• 2-CHLORO-5-(5-FORMYL-FURAN-2-YL)BENZOIC ACID METHYL ESTER
• 5-(4-CHLORO-2-NITRO-PHENYL)-FURAN-2-CARBOXYLIC ACID
• ASISCHEM W57383
• ETHYL 5-(4-CHLOROPHENYL)-2-FORMYL-3-FUROATE
• 5-(4-CHLORO-3-NITRO-PHENYL)-FURAN-2-CARBALDEHYDE
• ASISCHEM R44416
• 5-(4-BROMO-2-CHLOROPHENYL)-2-FURALDEHYDE
• 5-(3-chlorophenyl)-2-furaldehyde [4-[(2-furylmethyl)amino]-6-(4-methoxyanilino)-1,3,5-triazin-2-yl]hydrazone
• SPECS AK-968/37129155
• 2,2-DIBROMO-1-[5-(2,4-DICHLOROPHENYL)-2-FURYL]-1-ETHANONE
• 2-BROMO-1-[5-(2,4,6-TRICHLOROPHENYL)-2-FURYL]ETHAN-1-ONE