1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDE Chemical Properties

Melting point:

110-112 °C(Solv: ethyl ether (60-29-7); methanol (67-56-1))

storage temp. 

2-8°C

solubility 

DMSO: 10 mg/ml; PBS (pH 7.2): 1 mg/ml

form 

A crystalline solid

Safety Information

WGK Germany 

3

1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDE Usage And Synthesis

Description

1,4-dideoxy-1,4-imino-D-Arabinitol (DAB) is an inhibitor of glycogen phosphorylase, a key enzyme in glycogenolysis. It inhibits glycogenolysis in isolated liver cells (IC₅₀ = 1.0 μM) and in homogenates of cerebral cortex and cerebellum (IC₅₀s = 463 and 383 nM, respectively). DAB is used to inhibit glycogenolysis, in liver and in brain, in various animal models.

Uses

1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride has been used as an α-glucosidase (GAA) inhibitor.

General Description

1,4-Dideoxy-1,4-imino-D-arabinitol is a naturally occurring pyrrolidine alkaloid. It is found in Arachniodes standishii and Angylocalyx boutiqueanus.

Biochem/physiol Actions

Inhibitor of glycogen phosphorylase and α-glucosidases.

1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDE(100991-92-2)Related Product Information

• D-arabinitol
• 1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL