2-CHLORO-5-IODOPYRIDINE-3-CARBONITRILE Chemical Properties

Density 

2.13

storage temp. 

2-8°C(protect from light)

Appearance

Off-white to light brown Solid

Safety Information

HS Code 

2933399990

2-CHLORO-5-IODOPYRIDINE-3-CARBONITRILE Usage And Synthesis

Uses

2-Chloro-5-iodo-3-pyridinecarboxynitrile can be used as a pharmaceutical synthesis intermediate.

Synthesis

30.7 ml (329 mmol) of phosphoryl chloride at 0.7 C and 6 drops of sulfuric acid were added to 9 g (6.6 mmol) of 2-hydroxy-5-iodonicotinonitrile. The reaction mixture was heated at 110C for 5 hours and then at room temperature overnight. The reaction mixture was poured into a beaker containing ice and a small amount of water to form a precipitate. The mixture was allowed to gradually return to room temperature, then filtered and rinsed with water. The solid was dried to give 2-chloro-5-iodo-3-pyridinecarbonitrile.

2-CHLORO-5-IODOPYRIDINE-3-CARBONITRILE(766515-34-8)Related Product Information

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