5-ETHYL-2,4-PIPERIDINEDIONE Chemical Properties

Melting point:

72-74 °C

Boiling point:

156-157 °C(Press: 1 Torr)

Density 

1.060±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

12.04±0.70(Predicted)

5-ETHYL-2,4-PIPERIDINEDIONE Usage And Synthesis

Synthesis

The general procedure for the synthesis of 5-ethyl-2,4-piperidinedione from 1-Boc-5-ethyl-2,4-dioxopiperidine was as follows: 1-Boc-5-ethyl-2,4-dioxopiperidine was dissolved in trifluoroacetic acid (TFA, 10 mL), and the reaction was stirred for 2 h at room temperature. After completion of the reaction, the solvent was removed by rotary evaporator and the resulting residue was purified by column chromatography (eluent: hexane/ethyl acetate, 1:2, v/v) to afford 5-ethylpiperidine-2,4-dione in 52% yield. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-D6): δ 0.89 (t, J = 7.56 Hz, 3H), 1.35 (m, 1H), 1.69 (m, 1H), 2.39 (m, 1H), 3.14-3.38 (m, 4H), 8.05 (s, 1H); ESI (+) MS: m/z 142 (MH+) .

References

[1] Patent: US2007/142414, 2007, A1. Location in patent: Page/Page column 18
[2] Synthesis, 2007, # 20, p. 3185 - 3190

5-ETHYL-2,4-PIPERIDINEDIONE(73290-32-1)Related Product Information

• 2,4-Piperadinedione
• 5-ETHYL-3-PHENYL-6-(4,5,6,7-TETRAFLUORO-3-OXO-1,3-DIHYDRO-INDAZOL-2-YL)-PIPERIDINE-2,4-DIONE
• 5-ETHYL-2,4-PIPERIDINEDIONE
• 5-METHYL-2,4-PIPERIDINEDIONE