2-IODO-6-METHOXYPHENOL Chemical Properties

Boiling point:

233.2±20.0 °C(Predicted)

Density 

1.866±0.06 g/cm3(Predicted)

storage temp. 

2-8°C(protect from light)

pka

8.52±0.10(Predicted)

2-IODO-6-METHOXYPHENOL Usage And Synthesis

Definition

ChEBI: 2-iodo-6-methoxyphenol is a member of phenols and an organoiodine compound.

Synthesis

Methyl 3-(2-methoxyphenoxy)propionate (CAS: 165071-94-3, 52 g, 0.18 mol) was dissolved in methanol (400 mL) at 0 °C and 2 M methanolic solution of hydrochloric acid (100 mL) was slowly added. The reaction mixture was stirred at room temperature for 4 h. The solvent was removed by concentration under reduced pressure to afford 2-iodo-6-methoxyphenol (42 g, 95% yield).

References

[1] Patent: WO2010/94242, 2010, A1. Location in patent: Example 3.3
[2] Canadian Journal of Chemistry, 1987, vol. 65, p. 2019 - 2023

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