Methyl 4-chloro-6-methylnicotinate Chemical Properties

Melting point:

27-28℃

Boiling point:

253℃

Density 

1.247

Flash point:

107℃

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

-0.43±0.10(Predicted)

Appearance

Colorless to off-white <27°C Solid,>28°C Liquid

Safety Information

HS Code 

2933399990

Methyl 4-chloro-6-methylnicotinate Usage And Synthesis

Synthesis

The general procedure for the synthesis of methyl 2-chloro-6-methylpyridine-3-carboxylate from methanol and 2-chloro-6-methylnicotinic acid was as follows: a. Oxalyl chloride (9.3 mL) was slowly added to a solution of dichloromethane (500 mL) containing 2-chloro-6-methylnicotinic acid (9 g). The reaction mixture was stirred at room temperature for 30 min before the solvent was removed by concentration under reduced pressure to give the crude product. Subsequently, the crude product was dissolved in methanol (500 mL) and processed at 0 °C with stirring. After the reaction mixture was continued to be stirred at room temperature overnight, the solvent was again removed by concentration under reduced pressure to give the residue. The residue was diluted with water and ethyl acetate (EA), neutralized with saturated aqueous sodium bicarbonate solution and subsequently extracted three times with ethyl acetate. The organic layers were combined, washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give methyl 2-chloro-6-methylpyridine-3-carboxylate (9.7 g, 99% yield). The product was characterized by 1H NMR (400 MHz, chloroform-d): δ 2.60 (s, 3H), 3.95 (s, 3H), 7.17 (d, J = 7.8 Hz, 1H), 8.09 (d, J = 7.8 Hz, 1H).

References

[1] Patent: US2011/152312, 2011, A1. Location in patent: Page/Page column 35
[2] Patent: WO2009/100171, 2009, A1. Location in patent: Page/Page column 82
[3] Patent: US2010/144760, 2010, A1. Location in patent: Page/Page column 30; 31
[4] Patent: WO2010/72722, 2010, A1. Location in patent: Page/Page column 50
[5] Patent: WO2006/25783, 2006, A1. Location in patent: Page/Page column 65-66

Methyl 4-chloro-6-methylnicotinate(53277-47-7)Related Product Information

• Methyl nicotinate
• Methyl 6-methylnicotinate